Cargando…

FOXO1 mitigates the SMAD3/FOXL2(C134W) transcriptomic effect in a model of human adult granulosa cell tumor

BACKGROUND: Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.402C < G); however, the general molecular effect of this mutation and its...

Descripción completa

Detalles Bibliográficos
Autores principales:	Secchi, Christian, Benaglio, Paola, Mulas, Francesca, Belli, Martina, Stupack, Dwayne, Shimasaki, Shunichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913442/ https://www.ncbi.nlm.nih.gov/pubmed/33639972 http://dx.doi.org/10.1186/s12967-021-02754-0

Ejemplares similares

FOXO1 Mitigation of FOXL2C143W/SMAD3 Transcriptomic Landscape in a Model of Granulosa Cell Tumor
por: Secchi, Christian, et al.
Publicado: (2021)

FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3
por: Belli, Martina, et al.
Publicado: (2019)

A Novel Mouse Model for Studying the Effects of Cyp17 Overexpression in a Temporal- and Spatial-Specific Manner
por: Secchi, Christian, et al.
Publicado: (2021)

Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse
por: Secchi, Christian, et al.
Publicado: (2021)

Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter
por: Fleming, Nicholas I., et al.
Publicado: (2010)

The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours
por: Rosario, Roseanne, et al.
Publicado: (2012)

Overexpression of Wild-Type but Not C134W Mutant FOXL2 Enhances GnRH-Induced Cell Apoptosis by Increasing GnRH Receptor Expression in Human Granulosa Cell Tumors
por: Cheng, Jung-Chien, et al.
Publicado: (2013)

Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
por: Benayoun, Bérénice A., et al.
Publicado: (2010)

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target
por: Pierini, Stefano, et al.
Publicado: (2020)

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells
por: Anttonen, Mikko, et al.
Publicado: (2014)

Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
por: Wang, Wen-Chung, et al.
Publicado: (2014)

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis
por: Rosen, Emily R., et al.
Publicado: (2018)

Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease
por: Pilsworth, Jessica A, et al.
Publicado: (2021)

The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
por: Georges, Adrien, et al.
Publicado: (2014)

Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci
por: Fischer, Anne Kristin, et al.
Publicado: (2022)

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary
por: Kraus, Francois, et al.
Publicado: (2020)

FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells
por: Jin, Hanyong, et al.
Publicado: (2016)

Oleic acid induces down-regulation of the granulosa cell identity marker FOXL2, and up-regulation of the Sertoli cell marker SOX9 in bovine granulosa cells
por: Yenuganti, Vengala Rao, et al.
Publicado: (2017)

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter
por: Escudero, Jean M, et al.
Publicado: (2010)

Expression of FOXL2 and RSPO1 in Hen Ovarian Follicles and Implication of Exogenous Leptin in Modulating Their mRNA Expression in In Vitro Cultured Granulosa Cells
por: Niu, Weihe, et al.
Publicado: (2019)

Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles
por: Qin, Ning, et al.
Publicado: (2015)

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation
por: Yanagida, Satoshi, et al.
Publicado: (2017)

Transcriptome Profiling Analysis of Phosphate-Solubilizing Mechanism of Pseudomonas Strain W134
por: Wang, Shuaibing, et al.
Publicado: (2022)

FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens
por: Cui, Can, et al.
Publicado: (2019)

Differential Apoptotic and Proliferative Activities of Wild-type FOXL2 and Blepharophimosis-ptosis-epicanthus Inversus Syndrome (BPES)-associated Mutant FOXL2 Proteins
por: KIM, Jae-Hong, et al.
Publicado: (2013)

OR19-05 Human Induced Pluripotent Stem Cell-derived Granulosa-like Cells From Ligand-based Differentiation Express FOXL2 After Inhibition Of DKK1
por: Kubo, Hana, et al.
Publicado: (2023)

SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
por: Du, Xing, et al.
Publicado: (2020)

Sex determination and maintenance: the role of DMRT1 and FOXL2
por: Huang, Shengsong, et al.
Publicado: (2017)

FOXL1 overexpression is associated with poor outcome in patients with glioma
por: Chen, Ainian, et al.
Publicado: (2019)

FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants
por: Eozenou, Caroline, et al.
Publicado: (2020)

Transcriptome profiling of banana shrimp (Fenneropenaeus merguiensis) ovaries and testes: Insights into FoxL2
por: Potiyanadech, Wutthipat, et al.
Publicado: (2023)

Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells
por: Abdurahman, Anwar, et al.
Publicado: (2019)

Maximal Expression of Foxl2 in Pituitary Gonadotropes Requires Ovarian Hormones
por: Herndon, Maria K., et al.
Publicado: (2015)

Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium
por: Elbaz, Michal, et al.
Publicado: (2018)

Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells
por: Shen, M, et al.
Publicado: (2014)

FOXO3 regulates Smad3 and Smad7 through SPON1 circular RNA to inhibit idiopathic pulmonary fibrosis
por: Li, Hailong, et al.
Publicado: (2023)

Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas
por: Delaney, Joe Ryan, et al.
Publicado: (2016)

FOXL2 mutations in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome
por: Wang, Juan, et al.
Publicado: (2007)

Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
por: Garcia-Ortiz, José Elias, et al.
Publicado: (2009)

Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche
por: Aoki, Reina, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eh8q4t2vgqnnhdt1u6pvk8la8c