Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction. In the present study, we synthesized four novel analogues of...

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Detalles Bibliográficos
Autores principales: Mieczkowski, Adam, Speina, Elżbieta, Trzybiński, Damian, Winiewska-Szajewska, Maria, Wińska, Patrycja, Borsuk, Ewelina M., Podsiadła-Białoskórska, Małgorzata, Przygodzki, Tomasz, Drabikowski, Krzysztof, Stanczyk, Lidia, Zhukov, Igor, Watala, Cezary, Woźniak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913621/
https://www.ncbi.nlm.nih.gov/pubmed/33546456
http://dx.doi.org/10.3390/molecules26040794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913621/
https://www.ncbi.nlm.nih.gov/pubmed/33546456
http://dx.doi.org/10.3390/molecules26040794

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