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Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction. In the present study, we synthesized four novel analogues of...

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Detalles Bibliográficos
Autores principales:	Mieczkowski, Adam, Speina, Elżbieta, Trzybiński, Damian, Winiewska-Szajewska, Maria, Wińska, Patrycja, Borsuk, Ewelina M., Podsiadła-Białoskórska, Małgorzata, Przygodzki, Tomasz, Drabikowski, Krzysztof, Stanczyk, Lidia, Zhukov, Igor, Watala, Cezary, Woźniak, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913621/ https://www.ncbi.nlm.nih.gov/pubmed/33546456 http://dx.doi.org/10.3390/molecules26040794

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