A heme•DNAzyme activated by hydrogen peroxide catalytically oxidizes thioethers by direct oxygen atom transfer rather than by a Compound I-like intermediate

Hemin [Fe(III)-protoporphyrin IX] is known to bind tightly to single-stranded DNA and RNA molecules that fold into G-quadruplexes (GQ). Such complexes are strongly activated for oxidative catalysis. These heme•DNAzymes and ribozymes have found broad utility in bioanalytical and medicinal chemistry a...

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Detalles Bibliográficos
Autores principales: Shumayrikh, Nisreen M, Warren, Jeffrey J, Bennet, Andrew J, Sen, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913675/
https://www.ncbi.nlm.nih.gov/pubmed/33476369
http://dx.doi.org/10.1093/nar/gkab007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913675/
https://www.ncbi.nlm.nih.gov/pubmed/33476369
http://dx.doi.org/10.1093/nar/gkab007

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