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Mechanism of DNA cleavage by the endonuclease SauUSI: a major barrier to horizontal gene transfer and antibiotic resistance in Staphylococcus aureus

Acquisition of foreign DNA by Staphylococcus aureus, including vancomycin resistance genes, is thwarted by the ATP-dependent endonuclease SauUSI. Deciphering the mechanism of action of SauUSI could unravel the reason how it singularly plays a major role in preventing horizontal gene transfer (HGT) i...

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Detalles Bibliográficos
Autores principales: Tumuluri, Vinayak Sadasivam, Rajgor, Vrunda, Xu, Shuang-Yong, Chouhan, Om Prakash, Saikrishnan, Kayarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913695/
https://www.ncbi.nlm.nih.gov/pubmed/33533920
http://dx.doi.org/10.1093/nar/gkab042