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Dinucleotides as simple models of the base stacking-unstacking component of DNA ‘breathing’ mechanisms

Regulatory protein access to the DNA duplex ‘interior’ depends on local DNA ‘breathing’ fluctuations, and the most fundamental of these are thermally-driven base stacking-unstacking interactions. The smallest DNA unit that can undergo such transitions is the dinucleotide, whose structural and dynami...

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Detalles Bibliográficos
Autores principales: Beyerle, Eric R, Dinpajooh, Mohammadhasan, Ji, Huiying, von Hippel, Peter H, Marcus, Andrew H, Guenza, Marina G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913701/
https://www.ncbi.nlm.nih.gov/pubmed/33503257
http://dx.doi.org/10.1093/nar/gkab015