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Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter

Misregulation of BCL2 expression has been observed with many diseases and is associated with cellular exposure to reactive oxygen species. A region upstream of the P1 promoter in the human BCL2 gene plays a major role in regulating transcription. This G/C-rich region is highly polymorphic and capabl...

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Detalles Bibliográficos
Autores principales: Bielskutė, Stasė, Plavec, Janez, Podbevšek, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913773/
https://www.ncbi.nlm.nih.gov/pubmed/33638996
http://dx.doi.org/10.1093/nar/gkab057