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Oxidative lesions modulate G-quadruplex stability and structure in the human BCL2 promoter
Misregulation of BCL2 expression has been observed with many diseases and is associated with cellular exposure to reactive oxygen species. A region upstream of the P1 promoter in the human BCL2 gene plays a major role in regulating transcription. This G/C-rich region is highly polymorphic and capabl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913773/ https://www.ncbi.nlm.nih.gov/pubmed/33638996 http://dx.doi.org/10.1093/nar/gkab057 |