Design and Evaluation of a Polypeptide That Mimics the Integrin Binding Site for EDA Fibronectin to Block Profibrotic Cell Activity

Fibrosis is characterized by excessive production of disorganized collagen- and fibronectin-rich extracellular matrices (ECMs) and is driven by the persistence of myofibroblasts within tissues. A key protein contributing to myofibroblast differentiation is extra domain A fibronectin (EDA-FN). We sou...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Yan, Hongyu, Tai, Yifan, Xue, Yueming, Wei, Yongzhen, Wang, Kai, Zhao, Qiang, Wang, Shufang, Kong, Deling, Midgley, Adam C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913925/
https://www.ncbi.nlm.nih.gov/pubmed/33557232
http://dx.doi.org/10.3390/ijms22041575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913925/
https://www.ncbi.nlm.nih.gov/pubmed/33557232
http://dx.doi.org/10.3390/ijms22041575

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