A randomized phase 1 single-dose polysomnography study of ASP8062, a GABA(B) receptor positive allosteric modulator

RATIONALE: Previous research suggests that sleep polysomnography and EEG endpoints can be used to assess GABAergic activity; however, the impact of GABA(B) receptor positive allosteric modulators on sleep endpoints remains unclear. OBJECTIVES: This phase 1 study compared a single dose of ASP8062 (35...

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Detalles Bibliográficos
Autores principales: Walzer, Mark, Wu, Ruishan, Ahmad, Maha, Freeman, Jon, Zammit, Gary, Marek, Gerard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914186/
https://www.ncbi.nlm.nih.gov/pubmed/33433644
http://dx.doi.org/10.1007/s00213-020-05738-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914186/
https://www.ncbi.nlm.nih.gov/pubmed/33433644
http://dx.doi.org/10.1007/s00213-020-05738-y

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