Cargando…

PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression

Background: Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that symmetrically di-methylates arginine residues on both histone and non-histone protein substrates. Accumulating evidence suggests that PRMT5 exerts its oncogenic properties in a wide spectrum of huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Liu, Ma, Da-wei, Cao, Yue-peng, Li, Dong-zheng, Zhou, Xin, Feng, Ji-feng, Bao, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914347/ https://www.ncbi.nlm.nih.gov/pubmed/33664859 http://dx.doi.org/10.7150/thno.53023

Ejemplares similares

LncRNA MSTO2P promotes colorectal cancer progression through epigenetically silencing CDKN1A mediated by EZH2
por: Guo, Mengjun, et al.
Publicado: (2022)

Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression
por: Chen, Guobing, et al.
Publicado: (2018)

EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells
por: Stefansson, Olafur Andri, et al.
Publicado: (2011)

PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
por: Wang, Ji, et al.
Publicado: (2023)

EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling
por: Pang, Bo, et al.
Publicado: (2016)

PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis
por: Li, Zhongwei, et al.
Publicado: (2021)

Epigenetic repression of the Igk locus by STAT5-mediated Ezh2 recruitment
por: Mandal, Malay, et al.
Publicado: (2011)

MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21
por: Liu, Li, et al.
Publicado: (2017)

LINC00673 Represses CDKN2C and Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells by EZH2-Mediated H3K27 Trimethylation
por: Zhou, Menghan, et al.
Publicado: (2020)

CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition
por: Pinton, Giulia, et al.
Publicado: (2021)

CDKN1C (p57(KIP2)) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells
por: Yang, Xiaojing, et al.
Publicado: (2009)

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
por: Lui, Julian C., et al.
Publicado: (2016)

Correction: CDKN1C (p57(KIP2)) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells
por: Yang, Xiaojing, et al.
Publicado: (2009)

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a
por: Shields, Benjamin J., et al.
Publicado: (2016)

PUM1 represses CDKN1B translation and contributes to prostate cancer progression
por: Li, Xin, et al.
Publicado: (2021)

LINC00565 promotes the progression of colorectal cancer by upregulating EZH2
por: Shao, Xiaxia, et al.
Publicado: (2021)

Corrigendum: CDKN2A determines mesothelioma cell fate to EZH2 inhibition
por: Pinton, Giulia, et al.
Publicado: (2022)

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
por: Delgado-Olguín, Paul, et al.
Publicado: (2012)

Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
por: Gan, Lu, et al.
Publicado: (2018)

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
por: Sun, Yan, et al.
Publicado: (2023)

PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
por: Liu, Ming, et al.
Publicado: (2020)

ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma
por: Zheng, Yayuan, et al.
Publicado: (2022)

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
por: Béguelin, Wendy, et al.
Publicado: (2017)

Epigenetic silencing of CDKN1A and CDKN2B by SNHG1 promotes the cell cycle, migration and epithelial-mesenchymal transition progression of hepatocellular carcinoma
por: Li, Bei, et al.
Publicado: (2020)

Deregulation of Polycomb Repressive Complex-2 in Mantle Cell Lymphoma Confers Growth Advantage by Epigenetic Suppression of cdkn2b
por: Demosthenous, Christos, et al.
Publicado: (2020)

LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3
por: Zhou, Xin, et al.
Publicado: (2020)

Repressing the repressor: Ezh2 mediates macrophage activation
por: Neele, Annette E., et al.
Publicado: (2018)

PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer
por: Zhang, Xin, et al.
Publicado: (2021)

Long non-coding RNA SNHG1 promotes bladder cancer progression by upregulating EZH2 and repressing KLF2 transcription
por: Min, Jie, et al.
Publicado: (2022)

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer
por: Yu, Jindan, et al.
Publicado: (2010)

Expression of EZH2 is associated with poor outcome in colorectal cancer
por: Chen, Zhuanpeng, et al.
Publicado: (2018)

EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis
por: Yang, Yang, et al.
Publicado: (2017)

SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2
por: Guo, Jia, et al.
Publicado: (2021)

PRMT5 promotes colorectal cancer growth by interaction with MCM7
por: Li, Xiangwei, et al.
Publicado: (2021)

Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
por: Li, Yingze, et al.
Publicado: (2022)

Methylation of H2AR29 is a novel repressive PRMT6 target
por: Waldmann, Tanja, et al.
Publicado: (2011)

Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars
por: Jing, Junjun, et al.
Publicado: (2019)

Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1
por: Yan, Naihong, et al.
Publicado: (2016)

NBPF4 mitigates progression in colorectal cancer through the regulation of EZH2‐associated ETFA
por: Chen, Wankun, et al.
Publicado: (2021)

EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion
por: Yi, Xiaoqing, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ilsv7q9v5jihf9m0g5ogjc7q0q