Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors

Rationale: Aldehyde dehydrogenase (ALDH) enzymes are often upregulated in cancer cells and associated with therapeutic resistance. ALDH enzymes protect cells by metabolizing toxic aldehydes which can induce DNA double stand breaks (DSB). We recently identified a novel ALDH1A family inhibitor (ALDHi)...

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Detalles Bibliográficos
Autores principales: Grimley, Edward, Cole, Alexander J., Luong, Thong T., McGonigal, Stacy C., Sinno, Sarah, Yang, Dongli, Bernstein, Kara A., Buckanovich, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914353/
https://www.ncbi.nlm.nih.gov/pubmed/33664846
http://dx.doi.org/10.7150/thno.51885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914353/
https://www.ncbi.nlm.nih.gov/pubmed/33664846
http://dx.doi.org/10.7150/thno.51885

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