Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy

Arginine synthesis deficiency due to the suppressed expression of ASS1 (argininosuccinate synthetase 1) represents one of the most frequently occurring metabolic defects of tumor cells. Arginine-deprivation therapy has gained increasing attention in recent years. One challenge of ADI-PEG20 (pegylate...

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Detalles Bibliográficos
Autores principales: Chu, Cheng-Ying, Lee, Yi-Ching, Hsieh, Cheng-Han, Yeh, Chi-Tai, Chao, Tsu-Yi, Chen, Po-Hung, Lin, I-Hsuan, Hsieh, Tsung-Han, Shih, Jing-Wen, Cheng, Chia-Hsiung, Chang, Che-Chang, Lin, Ping-Sheng, Huang, Yuan-Li, Chen, Tsung-Ming, Yen, Yun, Ann, David K., Kung, Hsing-Jien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914361/
https://www.ncbi.nlm.nih.gov/pubmed/33664852
http://dx.doi.org/10.7150/thno.51795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914361/
https://www.ncbi.nlm.nih.gov/pubmed/33664852
http://dx.doi.org/10.7150/thno.51795

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