Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer

Background: In hypoxic tumors, positive feedback between oncogenic KRAS and HIF-1α involves impressive metabolic changes correlating with drug resistance and poor prognosis in colorectal cancer. Up to date, designed KRAS-targeting molecules do not show clear benefits in patient overall survival (POS...

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Detalles Bibliográficos
Autores principales: Cenigaonandia-Campillo, Aiora, Serna-Blasco, Roberto, Gómez-Ocabo, Laura, Solanes-Casado, Sonia, Baños-Herraiz, Natalia, Puerto-Nevado, Laura Del, Cañas, Jose Antonio, Aceñero, María Jesús, García-Foncillas, Jesús, Aguilera, Óscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914362/
https://www.ncbi.nlm.nih.gov/pubmed/33664850
http://dx.doi.org/10.7150/thno.51265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914362/
https://www.ncbi.nlm.nih.gov/pubmed/33664850
http://dx.doi.org/10.7150/thno.51265

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