An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors

A developing family of chemotherapeutics—derived from 5-(4-phenoxybutoxy)psoralen (PAP-1)—target mitochondrial potassium channel mtKv1.3 to selectively induce oxidative stress and death of diseased cells. The key to their effectiveness is the presence of a positively charged triphenylphosphonium gro...

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Detalles Bibliográficos
Autores principales: Parrasia, Sofia, Rossa, Andrea, Varanita, Tatiana, Checchetto, Vanessa, De Lorenzi, Riccardo, Zoratti, Mario, Paradisi, Cristina, Ruzza, Paolo, Mattarei, Andrea, Szabò, Ildikò, Biasutto, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914648/
https://www.ncbi.nlm.nih.gov/pubmed/33562146
http://dx.doi.org/10.3390/ph14020129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914648/
https://www.ncbi.nlm.nih.gov/pubmed/33562146
http://dx.doi.org/10.3390/ph14020129

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