Cargando…

An Angiopep2-PAPTP Construct Overcomes the Blood-Brain Barrier. New Perspectives against Brain Tumors

A developing family of chemotherapeutics—derived from 5-(4-phenoxybutoxy)psoralen (PAP-1)—target mitochondrial potassium channel mtKv1.3 to selectively induce oxidative stress and death of diseased cells. The key to their effectiveness is the presence of a positively charged triphenylphosphonium gro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parrasia, Sofia, Rossa, Andrea, Varanita, Tatiana, Checchetto, Vanessa, De Lorenzi, Riccardo, Zoratti, Mario, Paradisi, Cristina, Ruzza, Paolo, Mattarei, Andrea, Szabò, Ildikò, Biasutto, Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914648/ https://www.ncbi.nlm.nih.gov/pubmed/33562146 http://dx.doi.org/10.3390/ph14020129

Ejemplares similares

DA7R: A 7-Letter Zip Code to Target PDAC
por: Parrasia, Sofia, et al.
Publicado: (2023)

Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges
por: Parrasia, Sofia, et al.
Publicado: (2022)

Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo
por: Bachmann, Magdalena, et al.
Publicado: (2022)

Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents
por: Mattarei, Andrea, et al.
Publicado: (2018)

N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol
por: Mattarei, Andrea, et al.
Publicado: (2015)

New Water-Soluble Carbamate Ester Derivatives of Resveratrol
por: Mattarei, Andrea, et al.
Publicado: (2014)

Amino Acid Carbamates As Prodrugs Of Resveratrol
por: Mattarei, Andrea, et al.
Publicado: (2015)

Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family
por: Peruzzo, Roberta, et al.
Publicado: (2020)

Corrigendum to “Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family” [Redox Biol. 37 (2020 Sep 6) 101705–101721]
por: Peruzzo, Roberta, et al.
Publicado: (2021)

Regioselective O-Derivatization of Quercetin via Ester Intermediates. An Improved Synthesis of Rhamnetin and Development of a New Mitochondriotropic Derivative
por: Mattarei, Andrea, et al.
Publicado: (2010)

Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells
por: Peruzzo, Roberta, et al.
Publicado: (2017)

Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene
por: La Spina, Martina, et al.
Publicado: (2021)

Targeting mitochondrial ion channels for cancer therapy
por: Szabo, Ildiko, et al.
Publicado: (2020)

Homogeneous antibody–angiopep 2 conjugates for effective brain targeting
por: Anami, Yasuaki, et al.
Publicado: (2022)

Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model
por: Severin, Filippo, et al.
Publicado: (2022)

Angiopep-2-Modified Nanoparticles for Brain-Directed Delivery of Therapeutics: A Review
por: Habib, Saffiya, et al.
Publicado: (2022)

Influence of the Drug Position on Bioactivity in Angiopep-2—Daunomycin Conjugates
por: Pethő, Lilla, et al.
Publicado: (2023)

Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction
por: Peruzzo, Roberta, et al.
Publicado: (2021)

Determination of Quercetin and Resveratrol in Whole Blood—Implications for Bioavailability Studies
por: Biasutto, Lucia, et al.
Publicado: (2010)

Intracellular ion channels and cancer
por: Leanza, Luigi, et al.
Publicado: (2013)

Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier
por: Papademetriou, Iason, et al.
Publicado: (2018)

Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling
por: Urbani, Andrea, et al.
Publicado: (2021)

A brain glioma gene delivery strategy by angiopep-2 and TAT-modified magnetic lipid-polymer hybrid nanoparticles
por: Qiao, Lanxin, et al.
Publicado: (2020)

Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM)
por: di Polidoro, Angela Costagliola, et al.
Publicado: (2022)

Browning Effects of a Chronic Pterostilbene Supplementation in Mice Fed a High-Fat Diet
por: La Spina, Martina, et al.
Publicado: (2019)

Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive K(+) Channel
por: Kravenska, Yevheniia, et al.
Publicado: (2021)

Boron-peptide conjugates with angiopep-2 for boron neutron capture therapy
por: Xiang, Jing, et al.
Publicado: (2023)

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
por: Xie, Ruoxi, et al.
Publicado: (2021)

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma
por: Ji, Xuemei, et al.
Publicado: (2019)

Impact of intracellular ion channels on cancer development and progression
por: Peruzzo, Roberta, et al.
Publicado: (2016)

Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model
por: Li, Weiwei, et al.
Publicado: (2022)

Angiopep-2 as an Exogenous Chemical Exchange Saturation Transfer Contrast Agent in Diagnosis of Alzheimer's Disease
por: Wang, Chengguang, et al.
Publicado: (2022)

Angiopep-2 Modified Exosomes Load Rifampicin with Potential for Treating Central Nervous System Tuberculosis
por: Li, Han, et al.
Publicado: (2023)

Modification of graphene oxide by angiopep-2 enhances anti-glioma efficiency of the nanoscaled delivery system for doxorubicin
por: Zhao, Yue, et al.
Publicado: (2020)

Retracted: Angiopep-2 as an Exogenous Chemical Exchange Saturation Transfer Contrast Agent in Diagnosis of Alzheimer's Disease
por: Healthcare Engineering, Journal of
Publicado: (2023)

Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma
por: Zaccagnino, Angela, et al.
Publicado: (2016)

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma
por: Kadow, Stephanie, et al.
Publicado: (2022)

Angiopep-2/IP10-EGFRvIIIscFv modified nanoparticles and CTL synergistically inhibit malignant glioblastoma
por: Wang, Xuan, et al.
Publicado: (2018)

LETM1-Mediated K(+) and Na(+) Homeostasis Regulates Mitochondrial Ca(2+) Efflux
por: Austin, Shane, et al.
Publicado: (2017)

Author Correction: Angiopep-2/IP10-EGFRvIIIscFv modified nanoparticles and CTL synergistically inhibit malignant glioblastoma
por: Wang, Xuan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n41lpjh2ll2iagl5288hjt1reu