Cargando…

Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential

SIMPLE SUMMARY: Due to their intrinsic aggressiveness, cancer stem cells (CSCs) represent an essential target for the design of effective treatments against pancreatic cancer, one of the deadliest tumors. As pancreatic CSCs are particularly dependent on the activity of their mitochondria, we here fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Courtois, Sarah, de Luxán-Delgado, Beatriz, Penin-Peyta, Laure, Royo-García, Alba, Parejo-Alonso, Beatriz, Jagust, Petra, Alcalá, Sonia, Rubiolo, Juan A., Sánchez, Laura, Sainz, Bruno, Heeschen, Christopher, Sancho, Patricia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914708/ https://www.ncbi.nlm.nih.gov/pubmed/33572276 http://dx.doi.org/10.3390/cancers13040698

Ejemplares similares

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
por: Jagust, Petra, et al.
Publicado: (2019)

Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells
por: Jagust, Petra, et al.
Publicado: (2020)

Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer
por: Royo-García, Alba, et al.
Publicado: (2021)

Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification
por: Espiau-Romera, Pilar, et al.
Publicado: (2020)

The Anthrax Toxin Receptor 1 (ANTXR1) Is Enriched in Pancreatic Cancer Stem Cells Derived from Primary Tumor Cultures
por: Alcalá, Sonia, et al.
Publicado: (2019)

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells
por: Valle, Sandra, et al.
Publicado: (2020)

Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells
por: Alcalá, Sonia, et al.
Publicado: (2020)

Correction: Alcalá, S., et al. Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells. Int. J. Mol. Sci. 2020, 21, 7437
por: Alcalá, Sonia, et al.
Publicado: (2020)

Enhanced tumorigenicity by mitochondrial DNA mild mutations
por: Cruz-Bermúdez, Alberto, et al.
Publicado: (2015)

N-Heterocyclic Carbene Iron Complexes as Anticancer Agents: In Vitro and In Vivo Biological Studies
por: Lenis-Rojas, Oscar A., et al.
Publicado: (2021)

Metabolomic and Mitochondrial Fingerprinting of the Epithelial-to-Mesenchymal Transition (EMT) in Non-Tumorigenic and Tumorigenic Human Breast Cells
por: Cuyàs, Elisabet, et al.
Publicado: (2022)

The Fuss Over Lipo“fuss”cin: Not All Autofluorescence is the Same
por: Sainz, B., et al.
Publicado: (2015)

Hallmarks of cancer stem cell metabolism
por: Sancho, Patricia, et al.
Publicado: (2016)

Correction: Enhanced tumorigenicity by mitochondrial DNA mild mutations
por: Cruz-Bermúdez, Alberto, et al.
Publicado: (2020)

The dark side of radiotherapy-induced cell death in cancer
por: Alcalá, Sonia, et al.
Publicado: (2019)

Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative
por: Raitz, Ismael, et al.
Publicado: (2017)

Mitochondrial genetics – new model uncovering roles in tumorigenicity and metastasis
por: Beadnell, Thomas C., et al.
Publicado: (2018)

The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud
por: Okamoto, Koji, et al.
Publicado: (1998)

Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
por: Zheng, Quan, et al.
Publicado: (2023)

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer
por: Valle, Sandra, et al.
Publicado: (2018)

SYBR Gold dye enables preferential labelling of mitochondrial nucleoids and their time-lapse imaging by structured illumination microscopy
por: Jevtic, Visnja, et al.
Publicado: (2018)

Mitochondrial Translation Occurs Preferentially in the Peri-Nuclear Mitochondrial Network of Cultured Human Cells
por: Albus, Christin A., et al.
Publicado: (2021)

Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model
por: Santos-Ledo, Adrián, et al.
Publicado: (2021)

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo
por: Russell, Oliver M., et al.
Publicado: (2018)

Crossing-Over in a Hypervariable Species Preferentially Occurs in Regions of High Local Similarity
por: Seplyarskiy, Vladimir B., et al.
Publicado: (2014)

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
por: Lonardo, Enza, et al.
Publicado: (2015)

Rapamycin Response in Tumorigenic and Non-Tumorigenic Hepatic Cell Lines
por: Jimenez, Rosa H., et al.
Publicado: (2009)

Relationship between perception of smile esthetics and orthodontic treatment in Spanish patients
por: Bolas-Colvee, Belen, et al.
Publicado: (2018)

To Become or Not to Become Tumorigenic: Subventricular Zone Versus Hippocampal Neural Stem Cells
por: Fontán-Lozano, Ángela, et al.
Publicado: (2020)

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation
por: Wang, Bo, et al.
Publicado: (2021)

Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice
por: Bi, Pengpeng, et al.
Publicado: (2016)

miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes
por: Xu, Yong, et al.
Publicado: (2010)

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity
por: Kuo, Ching-Ying, et al.
Publicado: (2016)

Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
por: García-Macia, Marina, et al.
Publicado: (2019)

Morphological Abnormalities and Gene Expression Changes Caused by High Incubation Temperatures in Zebrafish Xenografts with Human Cancer Cells
por: Cabezas-Sainz, Pablo, et al.
Publicado: (2021)

Tumorigenicity of acridine orange.
por: Van Duuren, B. L., et al.
Publicado: (1969)

Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA
por: Malarkey, Christopher S., et al.
Publicado: (2012)

Mechanism of the Aza-Piancatelli Reaction: Scope and Limitations of Furan Substitution in Donor–Acceptor Stenhouse Adduct Synthesis
por: Peñín, Beatriz, et al.
Publicado: (2022)

In Vitro and In Vivo Biological Activity of Ruthenium 1,10-Phenanthroline-5,6-dione Arene Complexes
por: Lenis-Rojas, Oscar A., et al.
Publicado: (2022)

Nutrición en la cirugía bariátrica /
por: Sáinz Gómez, Beatriz
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_m3a9ib5n1hg4klhb3h7buueeg3