Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

SIMPLE SUMMARY: MLL-rearranged leukemia, driven by MLL-fusion proteins, is an aggressive, therapy-resistant leukemia found in >60% of infant leukemia and ~10% of adult leukemia. Studies have shown that inhibiting DOT1L enzymatic activity blocks leukemogenesis. However, DOT1L is critical for vario...

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Detalles Bibliográficos
Autores principales: Grigsby, Sierrah M., Friedman, Ann, Chase, Jennifer, Waas, Bridget, Ropa, James, Serio, Justin, Shen, Chenxi, Muntean, Andrew G., Maillard, Ivan, Nikolovska-Coleska, Zaneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914713/
https://www.ncbi.nlm.nih.gov/pubmed/33562706
http://dx.doi.org/10.3390/cancers13040642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914713/
https://www.ncbi.nlm.nih.gov/pubmed/33562706
http://dx.doi.org/10.3390/cancers13040642

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