Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly

Lipoyl synthase (LIAS) is an iron–sulfur cluster protein and a member of the radical S-adenosylmethionine (SAM) superfamily that catalyzes the final step of lipoic acid biosynthesis. The enzyme contains two [4Fe–4S] centers (reducing and auxiliary clusters) that promote radical formation and sulfur...

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Detalles Bibliográficos
Autores principales: Hendricks, Amber L., Wachnowsky, Christine, Fries, Brian, Fidai, Insiya, Cowan, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915201/
https://www.ncbi.nlm.nih.gov/pubmed/33562493
http://dx.doi.org/10.3390/ijms22041598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915201/
https://www.ncbi.nlm.nih.gov/pubmed/33562493
http://dx.doi.org/10.3390/ijms22041598

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