Allosteric Interactions between Adenosine A(2A) and Dopamine D(2) Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A(2A) and dopamine D(2) receptors (R). Stimulation of A(2A)R inhibits and blockade of A(2A)R enhances D(2)R-mediated locomotor activation and goal-directed behavior in rodents. In striat...

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Detalles Bibliográficos
Autores principales: Prasad, Kavya, de Vries, Erik F. J., Elsinga, Philip H., Dierckx, Rudi A. J. O., van Waarde, Aren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915359/
https://www.ncbi.nlm.nih.gov/pubmed/33572077
http://dx.doi.org/10.3390/ijms22041719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915359/
https://www.ncbi.nlm.nih.gov/pubmed/33572077
http://dx.doi.org/10.3390/ijms22041719

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