Cargando…

Allosteric Interactions between Adenosine A(2A) and Dopamine D(2) Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A(2A) and dopamine D(2) receptors (R). Stimulation of A(2A)R inhibits and blockade of A(2A)R enhances D(2)R-mediated locomotor activation and goal-directed behavior in rodents. In striat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Kavya, de Vries, Erik F. J., Elsinga, Philip H., Dierckx, Rudi A. J. O., van Waarde, Aren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915359/ https://www.ncbi.nlm.nih.gov/pubmed/33572077 http://dx.doi.org/10.3390/ijms22041719

Ejemplares similares

Impact of an Adenosine A(2A) Receptor Agonist and Antagonist on Binding of the Dopamine D(2) Receptor Ligand [(11)C]raclopride in the Rodent Striatum
por: Prasad, Kavya, et al.
Publicado: (2022)

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses
por: Sahlholm, Kristoffer, et al.
Publicado: (2015)

Binding of the Dual-Action Anti-Parkinsonian Drug AG-0029 to Dopamine D(2) and Histamine H(3) Receptors: A PET Study in Healthy Rats
por: Ghazanfari, Nafiseh, et al.
Publicado: (2022)

Decreased striatal adenosine A(2A)-dopamine D(2) receptor heteromerization in schizophrenia
por: Valle-León, Marta, et al.
Publicado: (2020)

Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET: Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [(11)C]MPDX
por: Sijbesma, Jürgen W. A., et al.
Publicado: (2016)

Hunting for the high‐affinity state of G‐protein‐coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging
por: Shalgunov, Vladimir, et al.
Publicado: (2018)

Effect of Dopamine D(2) Receptor Antagonists on [(18)F]-FEOBV Binding
por: Schildt, Anna, et al.
Publicado: (2020)

Radiation Dosimetry of a Novel Adenosine A(2A) Receptor Radioligand [(11)C]Preladenant Based on PET/CT Imaging and Ex Vivo Biodistribution in Rats
por: Zhou, Xiaoyun, et al.
Publicado: (2016)

In Vivo Induction of P-Glycoprotein Function can be Measured with [(18)F]MC225 and PET
por: García-Varela, Lara, et al.
Publicado: (2021)

Steroid hormones affect binding of the sigma ligand (11)C-SA4503 in tumour cells and tumour-bearing rats
por: Rybczynska, Anna A., et al.
Publicado: (2009)

PET/CT Imaging and Physiology of Mice on High Protein Diet
por: Sijbesma, Jürgen W. A., et al.
Publicado: (2021)

Pharmacokinetic Modeling of [(11)C]GSK-189254, PET Tracer Targeting H(3) Receptors, in Rat Brain
por: Ghazanfari, Nafiseh, et al.
Publicado: (2022)

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes
por: Amato, Sarah, et al.
Publicado: (2023)

Is cyclooxygenase‐1 involved in neuroinflammation?
por: Ghazanfari, Nafiseh, et al.
Publicado: (2021)

Conformational transitions and allosteric modulation in a heteromeric glycine receptor
por: Gibbs, Eric, et al.
Publicado: (2023)

Test–Retest Repeatability of [(18)F]MC225-PET in Rodents: A Tracer for Imaging of P-gp Function
por: García-Varela, Lara, et al.
Publicado: (2020)

Synthesis and evaluation in rats of homologous series of [(18)F]-labeled dopamine D(2/3) receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers
por: Shalgunov, Vladimir, et al.
Publicado: (2015)

Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503
por: Ramakrishnan, Nisha K., et al.
Publicado: (2015)

Avenues to molecular imaging of dying cells: Focus on cancer
por: Rybczynska, Anna A., et al.
Publicado: (2018)

Allosteric Recognition of Homomeric and Heteromeric Pairs of Monosaccharides by a Foldamer Capsule
por: Mateus, Pedro, et al.
Publicado: (2020)

Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
por: Bono, Federica, et al.
Publicado: (2020)

PET Imaging with S-[(11)C]Methyl-L-Cysteine and L-[Methyl-(11)C]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation
por: Parente, Andrea, et al.
Publicado: (2017)

Pharmacokinetic Modeling of [(18)F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET
por: García-Varela, Lara, et al.
Publicado: (2020)

Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications
por: Visser, Anniek K. D., et al.
Publicado: (2010)

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective
por: S. Clemente, Gonçalo, et al.
Publicado: (2020)

Allosteric modulation of adenosine receptors
por: Göblyös, Anikó, et al.
Publicado: (2008)

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study
por: Parente, Andrea, et al.
Publicado: (2020)

Allosteric modulation of the adenosine A(2A) receptor by cholesterol
por: Huang, Shuya Kate, et al.
Publicado: (2022)

Heteromeric assembly of P2X subunits
por: Saul, Anika, et al.
Publicado: (2013)

Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
por: García-Varela, Lara, et al.
Publicado: (2020)

Immunogold electron microscopic evidence of in situ formation of homo- and heteromeric purinergic adenosine A(1 )and P2Y(2 )receptors in rat brain
por: Namba, Kazunori, et al.
Publicado: (2010)

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo
por: de Bruyn, Marco, et al.
Publicado: (2010)

Positive allosteric modulation of the adenosine A(2a) receptor attenuates inflammation
por: Welihinda, Ajith A, et al.
Publicado: (2014)

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor
por: Johnstone, Elizabeth K. M., et al.
Publicado: (2022)

Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization
por: Fuxe, Kjell, et al.
Publicado: (2014)

Type 2β Corticotrophin Releasing Factor Receptor Forms a Heteromeric Complex With Dopamine D1 Receptor in Living Cells
por: Yarur, Hector E., et al.
Publicado: (2020)

Monitoring the Crosstalk Between the Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 with PET
por: Antunes, I. F., et al.
Publicado: (2020)

N-[(11)C]Methyl-AMD3465 PET as a Tool for In Vivo Measurement of Chemokine Receptor 4 (CXCR4) Occupancy by Therapeutic Drugs
por: Hartimath, S. V., et al.
Publicado: (2016)

Head-to-head comparison of (R)-[(11)C]verapamil and [(18)F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
por: García-Varela, Lara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_12r9nso0ntuhr40vdkpmb8sf8p