Differential Regulation of Bilastine Affinity for Human Histamine H(1) Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy

Bilastine, a zwitterionic second-generation antihistamine containing a carboxyl group, has higher selectivity for H(1) receptors than first-generation antihistamines. Ligand-receptor docking simulations have suggested that the electrostatic interaction between the carboxyl group of second-generation...

Descripción completa

Detalles Bibliográficos
Autores principales: Akimoto, Hayato, Sugihara, Minoru, Hishinuma, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915449/
https://www.ncbi.nlm.nih.gov/pubmed/33562121
http://dx.doi.org/10.3390/ijms22041655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915449/
https://www.ncbi.nlm.nih.gov/pubmed/33562121
http://dx.doi.org/10.3390/ijms22041655

Ejemplares similares