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Differential Regulation of Bilastine Affinity for Human Histamine H(1) Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy
Bilastine, a zwitterionic second-generation antihistamine containing a carboxyl group, has higher selectivity for H(1) receptors than first-generation antihistamines. Ligand-receptor docking simulations have suggested that the electrostatic interaction between the carboxyl group of second-generation...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915449/ https://www.ncbi.nlm.nih.gov/pubmed/33562121 http://dx.doi.org/10.3390/ijms22041655 |