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Pathological Circulating Factors in Moyamoya Disease

Moyamoya disease (MMD) is a cerebrovascular disease that presents with vascular stenosis and a hazy network of collateral formations in angiography. However, the detailed pathogenic pathway remains unknown. Studies have indicated that in addition to variations in the of genetic factor RNF213, unusua...

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Autores principales: Fang, Yao-Ching, Wei, Ling-Fei, Hu, Chaur-Jong, Tu, Yong-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915927/
https://www.ncbi.nlm.nih.gov/pubmed/33567654
http://dx.doi.org/10.3390/ijms22041696
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author Fang, Yao-Ching
Wei, Ling-Fei
Hu, Chaur-Jong
Tu, Yong-Kwang
author_facet Fang, Yao-Ching
Wei, Ling-Fei
Hu, Chaur-Jong
Tu, Yong-Kwang
author_sort Fang, Yao-Ching
collection PubMed
description Moyamoya disease (MMD) is a cerebrovascular disease that presents with vascular stenosis and a hazy network of collateral formations in angiography. However, the detailed pathogenic pathway remains unknown. Studies have indicated that in addition to variations in the of genetic factor RNF213, unusual circulating angiogenetic factors observed in patients with MMD may play a critical role in producing “Moyamoya vessels”. Circulating angiogenetic factors, such as growth factors, vascular progenitor cells, cytokines, inflammatory factors, and other circulating proteins, could promote intimal hyperplasia in vessels and excessive collateral formation with defect structures through endothelial hyperplasia, smooth muscle migration, and atypical neovascularization. This study summarizes the hypothesized pathophysiology of how these circulating factors affect MMD and the interactive modulation between them.
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spelling pubmed-79159272021-03-01 Pathological Circulating Factors in Moyamoya Disease Fang, Yao-Ching Wei, Ling-Fei Hu, Chaur-Jong Tu, Yong-Kwang Int J Mol Sci Review Moyamoya disease (MMD) is a cerebrovascular disease that presents with vascular stenosis and a hazy network of collateral formations in angiography. However, the detailed pathogenic pathway remains unknown. Studies have indicated that in addition to variations in the of genetic factor RNF213, unusual circulating angiogenetic factors observed in patients with MMD may play a critical role in producing “Moyamoya vessels”. Circulating angiogenetic factors, such as growth factors, vascular progenitor cells, cytokines, inflammatory factors, and other circulating proteins, could promote intimal hyperplasia in vessels and excessive collateral formation with defect structures through endothelial hyperplasia, smooth muscle migration, and atypical neovascularization. This study summarizes the hypothesized pathophysiology of how these circulating factors affect MMD and the interactive modulation between them. MDPI 2021-02-08 /pmc/articles/PMC7915927/ /pubmed/33567654 http://dx.doi.org/10.3390/ijms22041696 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fang, Yao-Ching
Wei, Ling-Fei
Hu, Chaur-Jong
Tu, Yong-Kwang
Pathological Circulating Factors in Moyamoya Disease
title Pathological Circulating Factors in Moyamoya Disease
title_full Pathological Circulating Factors in Moyamoya Disease
title_fullStr Pathological Circulating Factors in Moyamoya Disease
title_full_unstemmed Pathological Circulating Factors in Moyamoya Disease
title_short Pathological Circulating Factors in Moyamoya Disease
title_sort pathological circulating factors in moyamoya disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915927/
https://www.ncbi.nlm.nih.gov/pubmed/33567654
http://dx.doi.org/10.3390/ijms22041696
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