Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts

Pyruvate dehydrogenase kinase 1 (PDK1) blockade triggers are well characterized in vitro metabolic alterations in cancer cells, including reduced glycolysis and increased glucose oxidation. Here, by gene expression profiling and digital pathology-mediated quantification of in situ markers in tumors,...

Descripción completa

Detalles Bibliográficos
Autores principales: Venturoli, Carolina, Piga, Ilaria, Curtarello, Matteo, Verza, Martina, Esposito, Giovanni, Venuto, Santina, Navaglia, Filippo, Grassi, Angela, Indraccolo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915933/
https://www.ncbi.nlm.nih.gov/pubmed/33562444
http://dx.doi.org/10.3390/cells10020325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915933/
https://www.ncbi.nlm.nih.gov/pubmed/33562444
http://dx.doi.org/10.3390/cells10020325

Ejemplares similares