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Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts

Pyruvate dehydrogenase kinase 1 (PDK1) blockade triggers are well characterized in vitro metabolic alterations in cancer cells, including reduced glycolysis and increased glucose oxidation. Here, by gene expression profiling and digital pathology-mediated quantification of in situ markers in tumors,...

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Detalles Bibliográficos
Autores principales:	Venturoli, Carolina, Piga, Ilaria, Curtarello, Matteo, Verza, Martina, Esposito, Giovanni, Venuto, Santina, Navaglia, Filippo, Grassi, Angela, Indraccolo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915933/ https://www.ncbi.nlm.nih.gov/pubmed/33562444 http://dx.doi.org/10.3390/cells10020325

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