Exploring the Distinct Binding and Activation Mechanisms for Different CagA Oncoproteins and SHP2 by Molecular Dynamics Simulations

CagA is a major virulence factor of Helicobacter pylori. H. pylori CagA is geographically subclassified into East Asian CagA and Western CagA, which are characterized by the presence of a EPIYA-D or EPIYA-C segment. The East Asian CagA is more closely associated with gastric cancer than the Western...

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Detalles Bibliográficos
Autores principales: Wang, Quan, Zhao, Wen-Cheng, Fu, Xue-Qi, Zheng, Qing-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916045/
https://www.ncbi.nlm.nih.gov/pubmed/33562680
http://dx.doi.org/10.3390/molecules26040837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916045/
https://www.ncbi.nlm.nih.gov/pubmed/33562680
http://dx.doi.org/10.3390/molecules26040837

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