Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells

The reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium–proton exchangers (NHEs) that induce an acidic tu...

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Detalles Bibliográficos
Autores principales: Tavares-Valente, Diana, Sousa, Bárbara, Schmitt, Fernando, Baltazar, Fátima, Queirós, Odília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916175/
https://www.ncbi.nlm.nih.gov/pubmed/33572458
http://dx.doi.org/10.3390/pharmaceutics13020242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916175/
https://www.ncbi.nlm.nih.gov/pubmed/33572458
http://dx.doi.org/10.3390/pharmaceutics13020242

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