In Vitro and In Vivo Efficacy of a Novel Glucose–Methotrexate Conjugate in Targeted Cancer Treatment

Methotrexate (MTX) is a commonly used antimetabolite, which inhibits folate and DNA synthesis to be effective in the treatment of various malignancies. However, MTX therapy is hindered by the lack of target tumor selectivity. We have designed, synthesized and evaluated a novel glucose–methotrexate c...

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Detalles Bibliográficos
Autores principales: Woźniak, Marta, Pastuch-Gawołek, Gabriela, Makuch, Sebastian, Wiśniewski, Jerzy, Krenács, Tibor, Hamar, Peter, Gamian, Andrzej, Szeja, Wiesław, Szkudlarek, Danuta, Krawczyk, Monika, Agrawal, Siddarth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916191/
https://www.ncbi.nlm.nih.gov/pubmed/33572433
http://dx.doi.org/10.3390/ijms22041748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916191/
https://www.ncbi.nlm.nih.gov/pubmed/33572433
http://dx.doi.org/10.3390/ijms22041748

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