The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

BACKGROUND: In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte anabolism...

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Detalles Bibliográficos
Autores principales: Tanaka, Nobuho, Tsuno, Hirotaka, Ohashi, Satoru, Iwasawa, Mitsuyasu, Furukawa, Hiroshi, Kato, Tomohiro, Fukui, Naoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://www.ncbi.nlm.nih.gov/pubmed/33639898
http://dx.doi.org/10.1186/s12891-021-04096-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916266/
https://www.ncbi.nlm.nih.gov/pubmed/33639898
http://dx.doi.org/10.1186/s12891-021-04096-w

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