A New Computer Model for Evaluating the Selective Binding Affinity of Phenylalkylamines to T-Type Ca(2+) Channels

To establish a computer model for evaluating the binding affinity of phenylalkylamines (PAAs) to T-type Ca(2+) channels (TCCs), we created new homology models for both TCCs and a L-type calcium channel (LCC). We found that PAAs have a high affinity for domains I and IV of TCCs and a low affinity for...

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Detalles Bibliográficos
Autores principales: Lu, You, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916697/
https://www.ncbi.nlm.nih.gov/pubmed/33578931
http://dx.doi.org/10.3390/ph14020141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916697/
https://www.ncbi.nlm.nih.gov/pubmed/33578931
http://dx.doi.org/10.3390/ph14020141

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