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A New Computer Model for Evaluating the Selective Binding Affinity of Phenylalkylamines to T-Type Ca(2+) Channels
To establish a computer model for evaluating the binding affinity of phenylalkylamines (PAAs) to T-type Ca(2+) channels (TCCs), we created new homology models for both TCCs and a L-type calcium channel (LCC). We found that PAAs have a high affinity for domains I and IV of TCCs and a low affinity for...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916697/ https://www.ncbi.nlm.nih.gov/pubmed/33578931 http://dx.doi.org/10.3390/ph14020141 |