Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein (aSyn) and induces its aggregation. PREP inhibitors have been shown to have beneficial effects in Parkinson’s disease models by enhancing the clearance of aSyn aggregates and modulating striatal dopamine. Additionally, w...

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Detalles Bibliográficos
Autores principales: Julku, Ulrika H., Jäntti, Maria, Svarcbahs, Reinis, Myöhänen, Timo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916783/
https://www.ncbi.nlm.nih.gov/pubmed/33579026
http://dx.doi.org/10.3390/ijms22041777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916783/
https://www.ncbi.nlm.nih.gov/pubmed/33579026
http://dx.doi.org/10.3390/ijms22041777

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