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Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study

Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations...

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Autores principales: Zha, Ling, Liu, Rong, Sobue, Tomotaka, Kitamura, Tetsuhisa, Ishihara, Junko, Kotemori, Ayaka, Ikeda, Sayaka, Sawada, Norie, Iwasaki, Motoki, Tsugane, Shoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916863/
https://www.ncbi.nlm.nih.gov/pubmed/33670108
http://dx.doi.org/10.3390/nu13020590
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author Zha, Ling
Liu, Rong
Sobue, Tomotaka
Kitamura, Tetsuhisa
Ishihara, Junko
Kotemori, Ayaka
Ikeda, Sayaka
Sawada, Norie
Iwasaki, Motoki
Tsugane, Shoichiro
author_facet Zha, Ling
Liu, Rong
Sobue, Tomotaka
Kitamura, Tetsuhisa
Ishihara, Junko
Kotemori, Ayaka
Ikeda, Sayaka
Sawada, Norie
Iwasaki, Motoki
Tsugane, Shoichiro
author_sort Zha, Ling
collection PubMed
description Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations were found. This prospective study aimed to examine the association between dietary acrylamide intake and the risk of hematological malignancies, including malignant lymphoma (ML), multiple myeloma (MM), and leukemia. We enrolled 85,303 participants in the Japan Public Health Center-based Prospective study on diet and cancer as from 1995. A food frequency questionnaire that included data on acrylamide in all Japanese foods was used to assess dietary acrylamide intake. We applied multivariable adjusted Cox proportional hazards models to reckon hazard ratios (HRs) for acrylamide intake for both categorical variables (tertiles) and continuous variables. After 16.0 median years of follow-up, 326 confirmed cases of ML, 126 cases of MM, and 224 cases of leukemia were available for final multivariable-adjusted analysis. HRs were 0.87 (95% confidence interval [CI]: 0.64–1.18) for ML, 0.64 (95% CI: 0.38–1.05) for MM, and 1.01 (95% CI: 0.71–1.45) for leukemia. Our results implied that acrylamide may not be related to the risk of hematological malignancies.
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spelling pubmed-79168632021-03-01 Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study Zha, Ling Liu, Rong Sobue, Tomotaka Kitamura, Tetsuhisa Ishihara, Junko Kotemori, Ayaka Ikeda, Sayaka Sawada, Norie Iwasaki, Motoki Tsugane, Shoichiro Nutrients Article Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations were found. This prospective study aimed to examine the association between dietary acrylamide intake and the risk of hematological malignancies, including malignant lymphoma (ML), multiple myeloma (MM), and leukemia. We enrolled 85,303 participants in the Japan Public Health Center-based Prospective study on diet and cancer as from 1995. A food frequency questionnaire that included data on acrylamide in all Japanese foods was used to assess dietary acrylamide intake. We applied multivariable adjusted Cox proportional hazards models to reckon hazard ratios (HRs) for acrylamide intake for both categorical variables (tertiles) and continuous variables. After 16.0 median years of follow-up, 326 confirmed cases of ML, 126 cases of MM, and 224 cases of leukemia were available for final multivariable-adjusted analysis. HRs were 0.87 (95% confidence interval [CI]: 0.64–1.18) for ML, 0.64 (95% CI: 0.38–1.05) for MM, and 1.01 (95% CI: 0.71–1.45) for leukemia. Our results implied that acrylamide may not be related to the risk of hematological malignancies. MDPI 2021-02-11 /pmc/articles/PMC7916863/ /pubmed/33670108 http://dx.doi.org/10.3390/nu13020590 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zha, Ling
Liu, Rong
Sobue, Tomotaka
Kitamura, Tetsuhisa
Ishihara, Junko
Kotemori, Ayaka
Ikeda, Sayaka
Sawada, Norie
Iwasaki, Motoki
Tsugane, Shoichiro
Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title_full Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title_fullStr Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title_full_unstemmed Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title_short Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
title_sort dietary acrylamide intake and the risk of hematological malignancies: the japan public health center-based prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916863/
https://www.ncbi.nlm.nih.gov/pubmed/33670108
http://dx.doi.org/10.3390/nu13020590
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