Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway

Despite advances in neoadjuvant chemotherapy, outcomes for patients with osteosarcoma resistant to first-line chemotherapy have been dismal for decades. There is thus an urgent need to develop novel targeted drugs to effectively treat refractory osteosarcoma. Dysregulation in the PI3K/AKT pathway ha...

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Detalles Bibliográficos
Autores principales: Liang, Chao, Yu, Xijiao, Xiong, Naping, Zhang, Zhichang, Sun, Zhenyu, Dong, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917262/
https://www.ncbi.nlm.nih.gov/pubmed/33659212
http://dx.doi.org/10.3389/fonc.2020.615146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917262/
https://www.ncbi.nlm.nih.gov/pubmed/33659212
http://dx.doi.org/10.3389/fonc.2020.615146

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