Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

[Image: see text] This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of polyunsaturated fatty acids...

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Detalles Bibliográficos
Autores principales: Hammock, Bruce D., McReynolds, Cindy B., Wagner, Karen, Buckpitt, Alan, Cortes-Puch, Irene, Croston, Glenn, Lee, Kin Sing Stephen, Yang, Jun, Schmidt, William K., Hwang, Sung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917437/
https://www.ncbi.nlm.nih.gov/pubmed/33550801
http://dx.doi.org/10.1021/acs.jmedchem.0c01886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917437/
https://www.ncbi.nlm.nih.gov/pubmed/33550801
http://dx.doi.org/10.1021/acs.jmedchem.0c01886

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