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Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss

The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell-derived factor-1 (SDF1) is highly enriched in the bone marrow for C-X-C motif chemokine receptor 4 (CXCR4)-positive hematopoiet...

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Detalles Bibliográficos
Autores principales: Hu, Yan, Li, Xiaoqun, Zhang, Qin, Gu, Zhengrong, Luo, Ying, Guo, Jiawei, Wang, Xiuhui, Jing, Yingying, Chen, Xiao, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917458/
https://www.ncbi.nlm.nih.gov/pubmed/33718671
http://dx.doi.org/10.1016/j.bioactmat.2021.02.014