Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation

Metformin used as a first-line drug to treat Type 2 Diabetes Mellitus is transported via organic cation channels to soft tissues. Mutations in the SLC22A1 gene, such as Gly401Ser, Ser189Leu, and Arg206Cys, may affect the drug’s therapeutic effect on these patients. This study aims at proposing a pot...

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Detalles Bibliográficos
Autores principales: Cano, Leydy, Soto-Ospina, Alejandro, Araque, Pedronel, Caro-Gomez, Maria Antonieta, Parra-Marin, Maria Victoria, Bedoya, Gabriel, Duque, Constanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917475/
https://www.ncbi.nlm.nih.gov/pubmed/33658930
http://dx.doi.org/10.3389/fphar.2020.587590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917475/
https://www.ncbi.nlm.nih.gov/pubmed/33658930
http://dx.doi.org/10.3389/fphar.2020.587590

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