A Single Point Mutation, Asn(16)→Lys, Dictates the Temperature-Sensitivity of the Reovirus tsG453 Mutant

Studies of conditionally lethal mutants can help delineate the structure-function relationships of biomolecules. Temperature-sensitive (ts) mammalian reovirus (MRV) mutants were isolated and characterized many years ago. Two of the most well-defined MRV ts mutants are tsC447, which contains mutation...

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Detalles Bibliográficos
Autores principales: Glover, Kathleen K. M., Sutherland, Danica M., Dermody, Terence S., Coombs, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917769/
https://www.ncbi.nlm.nih.gov/pubmed/33673179
http://dx.doi.org/10.3390/v13020289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917769/
https://www.ncbi.nlm.nih.gov/pubmed/33673179
http://dx.doi.org/10.3390/v13020289

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