Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase †

Influenza A virus (IAV) encodes a polymerase composed of three subunits: PA, with endonuclease activity, PB1 with polymerase activity and PB2 with host RNA five-prime cap binding site. Their cooperation and stepwise activation include a process called cap-snatching, which is a crucial step in the IA...

Descripción completa

Detalles Bibliográficos
Autores principales: Gregor, Jiří, Radilová, Kateřina, Brynda, Jiří, Fanfrlík, Jindřich, Konvalinka, Jan, Kožíšek, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917969/
https://www.ncbi.nlm.nih.gov/pubmed/33673017
http://dx.doi.org/10.3390/molecules26041007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917969/
https://www.ncbi.nlm.nih.gov/pubmed/33673017
http://dx.doi.org/10.3390/molecules26041007

Ejemplares similares