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Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase †

Influenza A virus (IAV) encodes a polymerase composed of three subunits: PA, with endonuclease activity, PB1 with polymerase activity and PB2 with host RNA five-prime cap binding site. Their cooperation and stepwise activation include a process called cap-snatching, which is a crucial step in the IA...

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Detalles Bibliográficos
Autores principales:	Gregor, Jiří, Radilová, Kateřina, Brynda, Jiří, Fanfrlík, Jindřich, Konvalinka, Jan, Kožíšek, Milan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917969/ https://www.ncbi.nlm.nih.gov/pubmed/33673017 http://dx.doi.org/10.3390/molecules26041007

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