Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

Besides their antiviral and immunomodulatory functions, type I (α/β) and II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of abnormal CD5(+) B lymphocytes that escape death. Drug r...

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Detalles Bibliográficos
Autores principales: Bauvois, Brigitte, Pramil, Elodie, Jondreville, Ludovic, Quiney, Claire, Nguyen-Khac, Florence, Susin, Santos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918075/
https://www.ncbi.nlm.nih.gov/pubmed/33668421
http://dx.doi.org/10.3390/biomedicines9020188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918075/
https://www.ncbi.nlm.nih.gov/pubmed/33668421
http://dx.doi.org/10.3390/biomedicines9020188

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