Cargando…

Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

Besides their antiviral and immunomodulatory functions, type I (α/β) and II (γ) interferons (IFNs) exhibit either beneficial or detrimental effects on tumor progression. Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of abnormal CD5(+) B lymphocytes that escape death. Drug r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauvois, Brigitte, Pramil, Elodie, Jondreville, Ludovic, Quiney, Claire, Nguyen-Khac, Florence, Susin, Santos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918075/ https://www.ncbi.nlm.nih.gov/pubmed/33668421 http://dx.doi.org/10.3390/biomedicines9020188

Ejemplares similares

Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia
por: Bauvois, Brigitte, et al.
Publicado: (2020)

The Value of Neutrophil Gelatinase-Associated Lipocalin Receptor as a Novel Partner of CD38 in Chronic Lymphocytic Leukemia: From an Adverse Prognostic Factor to a Potential Pharmacological Target?
por: Bauvois, Brigitte, et al.
Publicado: (2023)

Small Molecule Inhibitors of Interferon‐Induced JAK‐STAT Signalling
por: Thoidingjam, Leishemba K., et al.
Publicado: (2022)

Extracellular Vesicles in Chronic Lymphocytic Leukemia: Tumor Microenvironment Messengers as a Basis for New Targeted Therapies?
por: Dubois, Kenza, et al.
Publicado: (2023)

P596: DELETION OF THE SHORT ARM OF CHROMOSOME 8 AND TNFRSF10B LOSS ASSOCIATE TO POOR PROGNOSIS AND DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA
por: Jondreville, Ludovic, et al.
Publicado: (2023)

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms
por: Verweij, Marieke C., et al.
Publicado: (2015)

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
por: Chmiest, Daniela, et al.
Publicado: (2016)

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
por: Kalliara, Eirini, et al.
Publicado: (2022)

Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?
por: Bauvois, Brigitte, et al.
Publicado: (2018)

JAK-STAT Signalling Pathway in Cancer
por: Brooks, Andrew J., et al.
Publicado: (2020)

JAK/STAT signaling in hepatocellular carcinoma
por: Hin Tang, Justin Jit, et al.
Publicado: (2020)

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses
por: Majoros, Andrea, et al.
Publicado: (2017)

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway
por: Au-Yeung, Nancy, et al.
Publicado: (2013)

JAK/STAT signaling and human in vitro myogenesis
por: Trenerry, Marissa K, et al.
Publicado: (2011)

JAK-STAT signaling and myocardial glucose metabolism
por: Frias, Miguel A, et al.
Publicado: (2013)

The role of JAK-STAT signaling within the CNS
por: Nicolas, Celine S., et al.
Publicado: (2013)

JAK/STAT signaling in diabetic kidney disease
por: Liu, Yingjun, et al.
Publicado: (2023)

Porcine Respirovirus 1 Suppresses Host Type I Interferon Production and the JAK-STAT Signaling Pathway
por: Li, Yanhua, et al.
Publicado: (2023)

Poly(C)-binding protein 2 positively regulates interferon downstream signaling: PCBP2 enhances JAK-STAT signaling
por: Huang, Chenxiao, et al.
Publicado: (2022)

A review of JAK–STAT signalling in the pathogenesis of spondyloarthritis and the role of JAK inhibition
por: McInnes, Iain B, et al.
Publicado: (2021)

Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway
por: Hurtado-Guerrero, Isaac, et al.
Publicado: (2017)

The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway
por: Li, Pengfei, et al.
Publicado: (2019)

JAK-STAT signaling in stem cells and their niches in Drosophila
por: Bausek, Nina
Publicado: (2013)

JAK/STAT Signalling in Huntington’s Disease Immune Cells
por: Träger, Ulrike, et al.
Publicado: (2013)

The Jak/Stat Signaling Pathway Is Downregulated at Febrile Temperatures
por: Nespital, Tobias, et al.
Publicado: (2012)

JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
por: Mohri, Tomomi, et al.
Publicado: (2012)

Targeting the tumor microenvironment: JAK-STAT3 signaling
por: Bournazou, Eirini, et al.
Publicado: (2013)

Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
por: de Freitas, Renata Mendes, et al.
Publicado: (2015)

Leptin-Induced JAK/STAT Signaling and Cancer Growth
por: Mullen, McKay, et al.
Publicado: (2016)

The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma
por: Ou, Alexander, et al.
Publicado: (2021)

The JAK/STAT signaling pathway: from bench to clinic
por: Hu, Xiaoyi, et al.
Publicado: (2021)

Is the JAK-STAT Signaling Pathway Involved in the Pathogenesis of Depression?
por: Gałecka, Małgorzata, et al.
Publicado: (2022)

The potential roles of JAK/STAT signaling in the progression of osteoarthritis
por: Zhou, Qingluo, et al.
Publicado: (2022)

3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation
por: Wu, Xiangju, et al.
Publicado: (2023)

Current Status of Novel Agents for the Treatment of B Cell Malignancies: What’s Coming Next?
por: Tannoury, Mariana, et al.
Publicado: (2022)

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
por: Boyle, D L, et al.
Publicado: (2015)

In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia
por: Omari, Sofia A., et al.
Publicado: (2023)

Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling
por: Wang, Xin, et al.
Publicado: (2021)

SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression
por: Zhang, Yali, et al.
Publicado: (2021)

Progenitor expansion in apc mutants is mediated by Jak/Stat signaling
por: Lin, Junji, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_n61rgopv04t2oadpr83ieesgev