Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice

The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is dependent on the choice of animal model used in preclinical studies. CWNAs bind to acetylcholinesterase and prevent the catalysis of acetylcholi...

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Detalles Bibliográficos
Autores principales: Marrero-Rosado, Brenda M., Stone, Michael F., de Araujo Furtado, Marcio, Schultz, Caroline R., Cadieux, C. Linn, Lumley, Lucille A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918218/
https://www.ncbi.nlm.nih.gov/pubmed/33672922
http://dx.doi.org/10.3390/ijms22041893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918218/
https://www.ncbi.nlm.nih.gov/pubmed/33672922
http://dx.doi.org/10.3390/ijms22041893

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