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Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice
The identification of improved medical countermeasures against exposure to chemical warfare nerve agents (CWNAs), a class of organophosphorus compounds, is dependent on the choice of animal model used in preclinical studies. CWNAs bind to acetylcholinesterase and prevent the catalysis of acetylcholi...
Autores principales: | Marrero-Rosado, Brenda M., Stone, Michael F., de Araujo Furtado, Marcio, Schultz, Caroline R., Cadieux, C. Linn, Lumley, Lucille A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918218/ https://www.ncbi.nlm.nih.gov/pubmed/33672922 http://dx.doi.org/10.3390/ijms22041893 |
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