Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through a similar mechanism by interacting within the...

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Detalles Bibliográficos
Autores principales: Duarte, Yorley, Rojas, Maximiliano, Canan, Jonathan, Pérez, Edwin G., González-Nilo, Fernando, García-Colunga, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918632/
https://www.ncbi.nlm.nih.gov/pubmed/33668529
http://dx.doi.org/10.3390/molecules26040998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918632/
https://www.ncbi.nlm.nih.gov/pubmed/33668529
http://dx.doi.org/10.3390/molecules26040998

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