5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology. In particular, Clk1 and -4 are overexpressed in several human tumors. Most of the potent...

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Detalles Bibliográficos
Autores principales: ElHady, Ahmed K., El-Gamil, Dalia S., Chen, Po-Jen, Hwang, Tsong-Long, Abadi, Ashraf H., Abdel-Halim, Mohammad, Engel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918793/
https://www.ncbi.nlm.nih.gov/pubmed/33668683
http://dx.doi.org/10.3390/molecules26041001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918793/
https://www.ncbi.nlm.nih.gov/pubmed/33668683
http://dx.doi.org/10.3390/molecules26041001

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