Increased Bone Resorption during Lactation in Pycnodysostosis

Pycnodysostosis, a rare autosomal recessive skeletal dysplasia, is caused by a deficiency of cathepsin K. Patients have impaired bone resorption in the presence of normal or increased numbers of multinucleated, but dysfunctional, osteoclasts. Cathepsin K degrades collagen type I and generates N-telo...

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Detalles Bibliográficos
Autores principales: Jansen, Ineke D.C., Papapoulos, Socrates E., Bravenboer, Nathalie, de Vries, Teun J., Appelman-Dijkstra, Natasha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918824/
https://www.ncbi.nlm.nih.gov/pubmed/33670411
http://dx.doi.org/10.3390/ijms22041810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918824/
https://www.ncbi.nlm.nih.gov/pubmed/33670411
http://dx.doi.org/10.3390/ijms22041810

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