Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors

Metastasis is the major cause of death in colorectal cancer and it has been proven that inhibiting an interaction between adenomatous polyposis coli (APC) and Rho guanine nucleotide exchange factor 4 (Asef) efficaciously restrain metastasis. However, current inhibitors cannot achieve a satisfying ef...

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Detalles Bibliográficos
Autores principales: He, Xinheng, Huang, Ning, Qiu, Yuran, Zhang, Jian, Liu, Yaqin, Yin, Xiao-Lan, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918825/
https://www.ncbi.nlm.nih.gov/pubmed/33670371
http://dx.doi.org/10.3390/molecules26040962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918825/
https://www.ncbi.nlm.nih.gov/pubmed/33670371
http://dx.doi.org/10.3390/molecules26040962

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