Cargando…
Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors
Metastasis is the major cause of death in colorectal cancer and it has been proven that inhibiting an interaction between adenomatous polyposis coli (APC) and Rho guanine nucleotide exchange factor 4 (Asef) efficaciously restrain metastasis. However, current inhibitors cannot achieve a satisfying ef...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918825/ https://www.ncbi.nlm.nih.gov/pubmed/33670371 http://dx.doi.org/10.3390/molecules26040962 |